Process R&D

“’Mother Nature’” has bestowed upon us gifts in its pure form but it gets contaminated while it is transferred or distributed. Ours challenges can be categorized in three ways:

Challenge I is to prevent it from contamination.

Challenge II is to bring back the compound in its natural or pure form without further contaminating nature.

Challenge III is to make the process economical such that our products like life saving drugs or food supplements are at the required purity, reduced price and a good substitute against import.

Nilsan Nishotech Systems Private Limited (NNSPL) has been offering innovative solutions to the Indian industry to meet both these challenges since last 27 years. We have had enduring foreign collaborations with companies like Rhodia- Orelis, France, Dr. Müller, Switzerland and Novasep, France that have always given us an edge on the technical know-how and quality of our service.

Over the past few years we have realized the need to engage in Process R&D for providing good technical support to our clients. With experts on board, this R&D effort would mainly involve key areas of the company’s focus viz. Membrane Separations such as Microfiltration, Ultrafiltration, Nanofiltration and Reverse Osmosis and also in the Chromatographic Separations of API’s, Pharmaceutical small/ large molecules, Generic Biotech molecules, Antibiotics, enzymes, dairy products, etc.

Process R&D is focused on two main aspects i.e. Feasibility studies and Scale-up studies via Pilot scale trials:

  • Feasibility Studies
  • It would involve optimizing parameters such as selection of a suitable membrane based on the molecular weight cut-off, material of construction and geometry, operating conditions like temperature, pressure, pH, flow-rates etc. Once the parameters have been optimized, theoretical projections for scale up shall be undertaken to check if further progressing shall be economically viable.

  • Pilot scale Studies
  • Once the feasibility studies have been successful, trials will now be conducted on larger volumes. This will involve optimizing the engineering keeping in mind the hydraulics, selection of pump, instrumentation, length of operation before cleaning etc. Cleaning in place (CIP) protocols shall be established. A scale down of the actual process shall be done. Results of these trials shall help us to accurately design and engineer the commercial scale plant with minimum errors.

Process R&D is focused on two main aspects i.e. Feasibility studies and Scale-up studies via Pilot scale trials:

  • Feasibility Studies
  • It would involve optimizing parameters such as selection of stationary and mobile phase, gradient, operating conditions like temperature, pH, flow-rates etc. which shall give us a proof of concept enabling us to carry forward the trials on a pilot scale.

  • Pilot scale Studies
  • Once the proof of concept has been established, trials will now be conducted keeping in mind the target production capacity. Breakthrough curves, thermodynamics & kinetics of sorption and desorption and overloading studies shall be undertaken to optimize the process which is economically viable. Simulation studies if required shall be conducted with the help of our leading partners Novasep.


Strict Standards: call_user_func_array() expects parameter 1 to be a valid callback, non-static method dc_jqaccordion::footer() should not be called statically in /home/nilsannishotech/public_html/wp-includes/plugin.php on line 525