Sequential Multicolumn Continuous Chromatography
Nilsan is a reputed provider of Sequential Multicolumn Chromatography systems in collaboration with Novasep, a world leader in chromatography technology. For decades, Novasep has worked on continuous Chromatography Process Development and has built the largest FDA-audited continuous chromatography platform at commercial scale. To adapt to the current bio pharma challenges, Novasep is committed to delivering expertise in Sequential Multicolumn Liquid Chromatography know-how by developing the state-of-the-art BioSC® Sequential Chromatography platform.
Applications
- MAbs
- Insulin
- Blood fractionation
- Recombinant proteins
- Vaccines and viral vectors
Features
- Adaptability: Operations from 1 up to 6 columns in batch, parallel batch, continuous chromatography or continuous process easy switch from batch to continuous, optimizing process parameters with BioSC® Predict software.
- Easy switch from batch to continuous, optimizing process parameters with BioSC® Predict software
- Reduction of media and buffer consumption by up to 75%
- Increased productivity by 2 to 6-fold
| Batch Chromatography | Continuous Chromatography |
| Single Column | Multiple Column in series |
| Each portion of the resin is working for a very short period of time |
Media is used at its maximum capacity |
| – | Target molecule is not lost |
| – | Load more & faster |
| Lab | Pilot | Industrial | |
|---|---|---|---|
| Number of Columns | 1 to 6 | ||
| Productivity Range (kg/day) | < 0.01 | 0.1 | Upon request |
| Typical Column Diameter (mm) | 5 to 16 | 25 to 150 | |
| Flow Rates Range (mL/min) | 1-30 | 35-1500 | |
| Standard Max Operating Pressure (bar) | 6 | 6 | |
| Dimensions WxHxD (cm) | 69x90x63 | 200x200x100 | |
| Weight (kg) | 120 | 500 | |
