Supercritical Fluid Chromatography
Prochrom® Supersep systems are ideal for any chiral resolution, complex mixture purification or natural extract isolation. These provide solutions for greener, faster and cost-effective separations using the Supercritical Fluid chromatography (SFC) principle.
Features
- The use of supercritical CO2 decreases the amount of organic solvent required by 5 to 20 fold
- Its unique CO2 recycling technology reduces CO2 consumption by up to 20 times, allowing you to drastically reduce both production costs and environmental impact
- Scalable and fast solution
- Stable, repeatable and robust process
- Industrial programmable logic controller (PLC) equipped with PC interface with validated software based on GAMP 5 and compliant with 21 CFR part 11
SFC offering includes
- Prochrom® SFC columns
- Prochrom® Supersep chromatography systems
1. Prochrom® SFC columns
Fully automated Hipersep HPLC systems are designed for process development, pilot-scale and production-scale chromatographic separations.
Features
- Preparative chromatography columns adapted to the high pressure requirement of SFC and based on Prochrom® DAC (Dynamic Axial Compression) technology
- The DAC system consists of a piston which maintains a dynamic axial compression on the stationary phase. This provides packing with an optimum bed density and stability ensuring an efficient separation, easy and direct scale-up and a consistent performance at any scale of production and over extended periods of time
| Column Diameter (mm) | 50 | 80 | 100 | 150 | 200 |
|---|---|---|---|---|---|
| Max. Bed Length (mm) | 350 | 450 | |||
| Pressure Rating (bar) | 300 | ||||
2. Prochrom® Supersep chromatography systems
Features
- Fully automated Supersep™ SFC systems are designed for process development and pilot-scale chromatographic separations
- A robust and efficient design
- Optimal industrial design allowing for 24/7 continuous operation
- High productivity and yield resulting from excellent process reproducibility
- Reliability of instrumentation and easy access for reduced maintenance
- Compatibility with separation methods developed on any analytical SFC system
- A cost-effective and environmentally friendly solution
- Flexible CO2 supply (gas or liquid) to minimize CAPEX and energy needs
- Patented CO2 recycling device to reduce CO2 consumption by 10 to 20 times
- Contained system for feed and fraction collection to prevent any toxic aerosols
- High-pressure cyclones for high recovery yields
- Proprietary automatic cleaning-in-place feature for faster product changeovers
- All SFC systems can be operated under cGMP conditions. They are fully qualified and extensively tested during factory acceptance testing (FAT) and site acceptance testing (SAT)
