Inline Buffer Dilution Systems

Nilsan has wide-ranging experience in designing, manufacturing and customizing in-line buffer dilution systems for very specific and critical needs of the pharma and biopharma industry. Our technology is based on using the most accurate mass flow and conductivity measuring devices and a specific control system to reach the highest reproducibility. These systems drastically reduce the volume and size of buffer tanks in biopharma manufacturing plants.
Our in-line buffer dilution systems include advanced, PAT (Process Analytical Technologies guidelines of the FDA) compliant features.

System Specification

  • Designed for 5X & 10X dilution of buffer solution with WFI water. Customized designs are available to take upto 20X
  • Flow rate range of 100 – 5000 LPH with accuracy of ± 1%
  • Mass flow based control
  • Conductivity control with accuracy of ± 1%
  • Mixing and control loop for pH control
  • Dedicated acid and base dosing pump for precise pH control
  • Sterile filtration before outlet with provision for in-situ integrity testing
  • In line heat exchanger for temperature control
  • Provision to do CIP of all fluid path & SIP of Sterile filter
  • Advanced control mechanism
  • 21 CFR part 11 Compliance system
  • PLC and SCADA based system